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  • Title: Biochemical characterization of angiotensin-converting enzyme in human neuroblastoma tissue.
    Author: Tani M, Mizuno K, Hashimoto S, Niimura S, Yabe R, Kunii N, Suenaga K, Watari H, Fukuchi S.
    Journal: Clin Exp Hypertens A; 1987; 9(2-3):267-71. PubMed ID: 3038387.
    Abstract:
    High activity of angiotensin-converting enzyme was demonstrated in human neuroblastoma tissue. This activity required the presence of chloride ion and was almost completely inhibited by a specific converting enzyme inhibitor captopril (10 nM), indicating that the activity measured is indeed angiotensin-converting enzyme. Furthermore, the biochemical features of the enzyme were closely similar to the well-known properties of human lung converting enzyme, such as molecular weight (290,000), optimum pH (8.0-8.5), the presence of glycoprotein residues, and dependence on chloride ion concentration. These results provide definitive evidence for the presence of true angiotensin-converting enzyme in human neuroblastoma tissue.
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