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  • Title: Localization of the mcf.2 transforming sequence to the X chromosome.
    Author: Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, Birg F, Birnbaum D.
    Journal: EMBO J; 1987 May; 6(5):1301-7. PubMed ID: 3038515.
    Abstract:
    A transforming sequence was identified using co-transfection of DNA from the human mammary carcinoma cell line MCF-7 and of a G418 resistance gene into NIH 3T3 cells, followed by tumor formation in athymic mice. This sequence, named mcf.2, was molecularly cloned. A transforming activity resides in a cosmid clone of 42 kb. mcf.2 did not cross-hybridize with the known oncogenes tested. In situ hybridization localized it on the X chromosome, probably at q27. This localization was confirmed by hybridization to a panel of human--rodent cell line DNAs.
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