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  • Title: Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.
    Author: Traynor JR, Corbett AD, Kosterlitz HW.
    Journal: Eur J Pharmacol; 1987 May 07; 137(1):85-9. PubMed ID: 3038579.
    Abstract:
    The opioid agonist and antagonist activities of diprenorphine have been tested in four in vitro bioassay preparations. Diprenorphine is an antagonist at delta-receptors in the hamster vas deferens, at mu-receptors in the rat vas deferens and at kappa-receptors in the rabbit vas deferens. In the guinea-pig ileum it is an antagonist at mu-receptors and an agonist at kappa-receptors.
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