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  • Title: Transforming potential of DNA of the human PLC/PRF/5 hepatoma cell line.
    Author: Iwamura Y, Mitamura K, Yanagi K, Hashimoto T, Kato K.
    Journal: Intervirology; 1986; 26(4):223-7. PubMed ID: 3038774.
    Abstract:
    DNA of the human PLC/PRF/5 hepatoma cell line can induce the appearance of colonies on soft agar after transfection of BK-BK cells (BALB/c mouse kidney cells partially transformed by BK virus). Blot hybridization analyses indicate that the transformants contained the hepatitis B virus DNA sequence. This sequence disappeared during serial passage of transformants. The amplification and rearrangement of the integrated BK virus genome appears to be specifically associated with transformation.
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