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  • Title: The early enhancer-promoter of BKV and host range for transformation.
    Author: de Ronde A, MacDonald M, Sol C, ter Schegget J, Wouters E, van Strien A, van der Noordaa J.
    Journal: Intervirology; 1987; 27(1):38-44. PubMed ID: 3038777.
    Abstract:
    The early genes of the human papovavirus BKV and simian virus 40 (SV40) show a different host range for transformation. The early region of SV40 efficiently transforms human fibroblast cells, whereas the early region of BKV does not. Interchanging noncoding enhancer-promoter sequences around the origin of replication between BKV and SV40 showed that the early enhancer-promoter sequences of BKV and SV40 could substitute for each other, as far as the induction of expression of tumor antigens and morphological transformation is concerned; the efficiency of transformation was influenced by the enhancer-promoter sequences, and the difference in host range for transformation between BKV and SV40 was determined by the early gene products rather than by the enhancer-promoter sequences.
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