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  • Title: Identification and characterisation of a novel small galectin in razor clam (Sinonovacula constricta) with multiple innate immune functions.
    Author: Bai Y, Niu D, Li Y, Bai Y, Lan T, Peng M, Dong Z, Sun F, Li J.
    Journal: Dev Comp Immunol; 2019 Apr; 93():11-17. PubMed ID: 30389517.
    Abstract:
    Galectins are lectins possessing an evolutionarily conserved carbohydrate recognition domain (CRD) with affinity for β-galactoside. The key role played by innate immunity in invertebrates has recently become apparent. Herein, a full-length galectin (ScGal) was identified in razor clam (Sinonovacula constricta). The 528 bp open reading frame encodes a polypeptide of 176 amino acids with a single CRD and no signal peptide. ScGal mRNA transcripts were mainly expressed in hemolymph and gill, and were significantly up-regulated following bacterial challenge. Recombinant rScGal protein binds to and aggregates various bacteria, and has affinity for peptidoglycan, lipoteichoic acid and d-galactose. The protein also stimulates hemocytes to phagocytose invading bacterial pathogens. ScGal is an important immune factor in innate immunity, and a small protein with multiple important functions.
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