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  • Title: Structure and expression in Escherichia coli of canine interferon-alpha genes.
    Author: Himmler A, Hauptmann R, Adolf GR, Swetly P.
    Journal: J Interferon Res; 1987 Apr; 7(2):173-83. PubMed ID: 3039013.
    Abstract:
    Using a human interferon-alpha (IFN-alpha) cDNA probe, several recombinant phages containing type I IFN genes were isolated from a canine genomic library. One of these phages contains two complete CaIFN-alpha genes with identical coding sequences, and a second one a slightly different IFN-alpha gene. The IFN-alpha protein sequences contain six cysteine residues as well as two or three potential N-glycosylation sites. Expression of mature CaIFN-alpha 1 in E. coli results in antiviral activity on dog cells. Genomic analysis using an equine IFN-omega probe and DNA sequencing suggests the deletion of IFN-omega genes from canine genome.
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