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  • Title: Altered platelet phosphatidylinositol metabolism in essential hypertension.
    Author: Dimitrov D, Resink TJ, Müller FB, Bühler FR.
    Journal: J Hypertens Suppl; 1986 Dec; 4(6):S346-8. PubMed ID: 3039092.
    Abstract:
    The metabolism of phosphoinositides was investigated in platelet membranes from nine patients with essential hypertension (EHT) and from 10 age/sex-matched normotensive subjects. 32P-labelling or phosphatidic acid (PA), phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2) was measured in lipid extracts prepared from resting 32P-prelabelled platelets. There were no differences in 32P-PA between subject groups. In platelets of hypertensive patients, 32P-incorporation into both PIP and PIP2 was greater (P at least less than 0.01). This increase apparently occurred at the expense of lower 32P-incorporation into PI (P less than 0.001). An alteration in the interconversion equilibrium between phosphoinositides which is directed towards polyphosphoinositide formation may lead to altered membrane ionic fluxes.
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