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  • Title: Conventional MR-based Preoperative Nomograms for Prediction of IDH/1p19q Subtype in Low-Grade Glioma.
    Author: Liu Z, Zhang T, Jiang H, Xu W, Zhang J.
    Journal: Acad Radiol; 2019 Aug; 26(8):1062-1070. PubMed ID: 30393056.
    Abstract:
    RATIONALE AND OBJECTIVES: To develop nomogram models incorporating MR and clinical features for preoperative prediction of isocitrate dehydrogenase (IDH)/1p19q subtype in patients with lower-grade gliomas (LGG). MATERIALS AND METHODS: We classified LGG (149 patients) into three categories: (1) IDH mutation and 1p/19q codeletion, (2) IDH mutation and no 1p/19q codeletion, and (3) wild-type IDH. The correlation between clinical and MR features and IDH/1p19q subtype was analyzed. RESULTS: (1) Multivariate analysis showed that hemorrhage (yes vs no odds ratio [OR]: 12.775), enhancing margin (poorly vs well defined OR: 17.87), and SVZ (SVZ+ vs SVZ- OR: 0.304 were associated with a higher incidence of IDHmut-codel status (All p < 0.05). (2) Multivariate analysis showed that age (≥40 years vs <40 years OR: 0.139), hemorrhage (yes vs no OR: 0.095), enhancing margin (poorly vs well defined OR: 0.275), volume (>60 cm3 vs ≤60 cm3 OR: 5.111), and the shortest distance from the tumor centroid to the edge of the lateral ventricles (CS) (>30 mm vs ≤30 mm OR: 3.766) were associated with a higher incidence of IDHmut-noncodel status. (3) Multivariate analysis showed age (≥40 years vs <40 years OR: 17.311), tumor site (other vs frontal lobe OR: 4.696), volume (>60 cm3 vs ≤60 cm3 OR: 0.188), CS (>30 mm vs ≤30 mm OR: 0.285), necrosis (yes vs no OR: 0.193), and proportion CE tumor (>5% vs ≤5% OR: 5.253) were associated with a higher incidence of IDHwt status. Three nomogram models showed good discrimination (all area under the curve > 0.8) and calibration. CONCLUSION: Clinical and MR features may therefore be used to facilitate the preoperative prediction of LGG IDH/1p19q subtype.
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