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  • Title: Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.
    Author: Trepel JB, Colamonici OR, Kelly K, Schwab G, Watt RA, Sausville EA, Jaffe ES, Neckers LM.
    Journal: Mol Cell Biol; 1987 Jul; 7(7):2644-8. PubMed ID: 3039354.
    Abstract:
    Treatment of HL-60 cells with dibutyryl cyclic AMP induced rapid transcriptional inactivation of c-myc and the transferrin receptor. Transcriptional inactivation was followed by loss of c-myc and transferrin receptor mRNA and protein. Treated cells completed one round of proliferation, followed by growth arrest, G1 synchronization, and monocytic differentiation. These data suggest that cyclic AMP-mediated control of growth and differentiation may be achieved, at least in part, by transcriptional regulation of certain growth-associated proto-oncogenes and growth factor receptor genes.
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