These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Postsynaptic inhibition of the frog neuromuscular transmission by prostaglandin E1.
    Author: Tsurusaki M, Tokimasa T, Akasu T.
    Journal: Neurosci Lett; 1987 Jun 26; 77(3):303-7. PubMed ID: 3039417.
    Abstract:
    Intracellular recordings were made from the frog sartorius muscle end plate. Prostaglandin (PG) E1 (100 nM-10 microM) decreased the amplitude of the end plate potential (EPP). PGE1 decreased the quantal size of EPPs, while it rather increased the quantum content. The frequency of miniature (m) EPPs was not affected by PGE1. PGE1 depressed the acetylcholine (ACh)-induced depolarization, as well as the amplitude of mEPPs. These results suggest that PGE1 decreases the sensitivity of nicotinic ACh receptors at the end plate membrane, resulting in postsynaptic depressions of neuromuscular transmission.
    [Abstract] [Full Text] [Related] [New Search]