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  • Title: Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices.
    Author: Miyamoto KI, Sato T, Abe M, Wagner T, Schöning MJ, Yoshinobu T.
    Journal: Micromachines (Basel); 2016 Jul 01; 7(7):. PubMed ID: 30404286.
    Abstract:
    A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.
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