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  • Title: Free radical modification of low-density lipoprotein: mechanisms and biological consequences.
    Author: Heinecke JW.
    Journal: Free Radic Biol Med; 1987; 3(1):65-73. PubMed ID: 3040538.
    Abstract:
    Low-density lipoprotein readily undergoes lipid peroxidation that is accompanied by apoprotein fragmentation. Oxidized forms of low-density lipoprotein show altered biological behavior, including changes in receptor recognition and cytotoxicity to cells in culture. In this review, free radical mechanisms and the biological consequences of low-density lipoprotein modification are discussed.
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