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  • Title: Toluene diisocyanate respiratory reactions. I. Reassessment of the problem.
    Author: Patterson R, Hargreave FE, Grammer LC, Harris KE, Dolovich J.
    Journal: Int Arch Allergy Appl Immunol; 1987; 84(1):93-100. PubMed ID: 3040596.
    Abstract:
    A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.
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