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  • Title: Schwann cell-conditioned medium supports neurite outgrowth and survival of spinal cord neurons in culture.
    Author: Bosch EP, Assouline JG, Pantazis NJ, Lim R.
    Journal: Muscle Nerve; 1988 Apr; 11(4):324-30. PubMed ID: 3041275.
    Abstract:
    The effect of Schwann cell-conditioned medium (SCM) on the development in vitro of spinal cord neurons was studied. Spinal cord neurons from 18-day-old rat embryos were cultured in serum-free conditioned medium obtained from confluent rat Schwann cells. In cultures fed SCM, the cells developed typical neuronal morphology and were identified by indirect immunofluorescence using a monoclonal antibody to neurofilament protein. SCM stimulated neurite outgrowth and supported survival of spinal cord neurons. Preliminary characterization suggests that the neurotrophic factor in SCM appears to be a protein with a molecular weight greater than 8000 daltons.
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