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  • Title: Improved synthesis of the Kijanimicin oligodeoxytetrasaccharide.
    Author: Thiem J, Sajus H.
    Journal: Carbohydr Res; 2019 Jan 01; 471():19-27. PubMed ID: 30412829.
    Abstract:
    By sequential synthesis the four 2,6-dideoxy saccharide moieties of the kijanimicin tetrasaccharide could be stereoselectively assembled. For formation of all required 2-deoxy α-glycoside linkages various S-(hexopyranosyl)-phosphorodithioates as donor structures could be convincingly employed. The terminal 2-deoxy β-glycoside linkage was stereoselectively formed following the dibromomethyl methyl ether approach. The target octadeoxy-tetrasaccha-ride could be obtained via nine subsequent steps in 5% overall yield.
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