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  • Title: Macrophage dependency of T-lymphocyte mitogenesis by Nocardia rubra cell-wall skeleton.
    Author: Sugimura K, Uemiya M, Azuma I, Yamawaki M, Yamamura Y.
    Journal: Microbiol Immunol; 1977; 21(9):525-30. PubMed ID: 304149.
    Abstract:
    The mitogenic activity of the cell-wall skeleton (CWS) of Nocardia rubra on purified splenic T-cells (thymus-derived lymphocytes) was investigated. N. rubra CWS showed remarkable mitogenic activity on normal spleen cells of C57BL/6J mice at concentrations ranging from 10 to 100 microgram per milliliter of culture medium, while, on purified splenic T-cells, N. rubra CWS did not act as an mitogen at any concentration. However, mitogenic activity of N. rubra CWS on T-cells was restored if purified splenic T-cells was reconstituted with X-irradiated peritoneal exudate cells (macrophages). The above results suggest the necessity of macrophages for T-lymphocyte activation by N. rubra CWS as well as PHA-P or Con A.
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