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  • Title: Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia.
    Author: Hoang T, Haman A, Goncalves O, Wong GG, Clark SC.
    Journal: Blood; 1988 Aug; 72(2):823-6. PubMed ID: 3042049.
    Abstract:
    The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors.
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