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  • Title: Current strategies and future prospects for enhancing microbial production of citric acid.
    Author: Hu W, Li WJ, Yang HQ, Chen JH.
    Journal: Appl Microbiol Biotechnol; 2019 Jan; 103(1):201-209. PubMed ID: 30421107.
    Abstract:
    Aspergillus niger and Yarrowia lipolytica are highly important in citric acid (CA) production. To further minimize the cost of CA bio-production using A. niger and Y. lipolytica, some strategies (e.g., metabolic engineering, efficient mutagenesis, and optimal fermentation strategies) were developed to enhance CA production and low-cost carbon sources were also utilized to decrease CA bio-production cost. In this review, we summarize the recent significant progresses in CA bio-production, including metabolic engineering, efficient mutagenesis and screening methods, optimal fermentation strategies, and use of low-cost carbon sources, and future prospects in this field are also discussed, which could help in the development of CA production industry.
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