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  • Title: The expression of S-100 protein and neuron-specific enolase in meningiomas.
    Author: Jitawi SA, Cochran AJ, Cancilla PA, Wen DR.
    Journal: Dis Markers; 1988 Jun; 6(2):109-17. PubMed ID: 3042261.
    Abstract:
    The distribution of S-100 protein and neuron-specific enolase (NSE) was examined in 19 meningiomas using the peroxidase-antiperoxidase (PAP) immunohistochemical technique. Positive cytoplasmic staining for NSE was observed in 16 tumors, and comparable staining for S-100 protein was observed in eight tumors. The finding of S-100 protein and NSE immunoreactivity in fibroblastic, meningiotheliomatous, and transitional meningiomas raises the possibility that these morphologically distinct neoplasms derive from a common pluripotential cell capable of differentiation along diverse paths.
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