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  • Title: The Catalytic Enantioselective Ugi Four-Component Reactions.
    Author: Shaabani S, Dömling A.
    Journal: Angew Chem Int Ed Engl; 2018 Dec 10; 57(50):16266-16268. PubMed ID: 30431219.
    Abstract:
    Finally stereoselective: Enantioselective variations have been developed for many multicomponent reactions; however, it has been missing for the Ugi four-component reaction. This has now changed with the discovery of an efficient catalytic enantioselective variant for the four-component reaction of isocyanides, primary amines, aldehydes or ketones, and carboxylic acids.
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