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  • Title: [Comparison of methods for evaluating the nephrotoxicity of cisplatin].
    Author: Suzumori K, Yasui Y, Suzumori K, Yagami Y, Seki T.
    Journal: Gan To Kagaku Ryoho; 1988 Aug; 15(8):2251-6. PubMed ID: 3044273.
    Abstract:
    The BUN, serum creatinine, creatinine clearance and the urinary excretion of leucine aminopeptidase (LAP), alkaline phosphatase (ALP), beta 2-microglobulin (beta-m), and N-acetyl-beta-glucosaminidase (NAG), were measured in 21 gynecological cancer patients treated with CAPF (CPA + ADM + CDDP + 5-FU) to evaluate the sensitivity of these indices to renal tubular damage. After receiving CDDP almost all patients displayed an increase in excretion of beta-m but no urinary enzyme activities. However, NAG index (NAG activity/urinary creatinine) rose markedly in all patients. We concluded that NAG index is a valuable method in providing sensitive indices for detecting renal tubular damage caused by CDDP.
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