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  • Title: Platelet adherence to cardiac and noncardiac endothelial cells in culture: lack of a prostacyclin effect.
    Author: Johnson CM, Helgeson SC.
    Journal: J Lab Clin Med; 1988 Sep; 112(3):372-9. PubMed ID: 3045233.
    Abstract:
    Cardiac tissues show a propensity to develop nonbacterial thrombotic endocarditis, a meshwork of platelets and fibrin. This lesion may cause a predisposition to subsequent colonization by circulating microorganisms, leading to infective endocarditis. We measured platelet adherence in vitro to cultured endothelial cells derived from the porcine aortic valve and ascending aorta. We found that valvular endothelial cells showed a twofold to threefold higher adherence than ascending aortic endothelial cells of chromium 51-labeled platelets in the presence of proteolytically active thrombin. This finding did not correlate with endothelial prostacyclin release: cardiac valve endothelial cells released more prostacyclin than did, ascending aortic cells, exogenous prostacyclin had no effect on thrombin-stimulated adherence, and aspirin inhibition of endothelial prostacyclin synthesis showed no effect on platelet adherence. Fixation of platelets abolished thrombin-stimulated adherence; fixation of endothelial cells had minimal effect. We suggest that these differences may contribute to the propensity of the cardiac valve to develop nonbacterial thrombotic endocarditis.
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