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  • Title: Minocycline prevents peroxidative permeabilization of cardiolipin-containing bilayer lipid membranes mediated by cytochrome c.
    Author: Firsov AM, Kotova EA, Antonenko YN.
    Journal: Biochem Biophys Res Commun; 2018 Dec 09; 507(1-4):510-513. PubMed ID: 30454899.
    Abstract:
    Peroxidase activity of cytochrome c stimulated by interaction of the protein with cardiolipin is considered to be involved in the induction of mitochondrial apoptosis associated with cytochrome c release from mitochondria. In model systems, this activity has been previously shown to cause permeabilization of cardiolipin-containing membranes. Here, we found that the antibiotic minocycline, known to have neuroprotective properties, inhibited both the binding of cyt c to cardiolipin-containing membranes and the cyt c/H2O2-induced liposome permeabilization. The results could be relevant to inhibition of cyt c release from mitochondria exerted by minocycline.
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