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  • Title: Fluctuating PEEP (F-PEEP) versus conventional PEEP in dogs with asymmetrical lung injury.
    Author: Inaba H, Sato J, Uchida H, Sakurada M, Ohwada T, Mizuguchi T.
    Journal: Acta Anaesthesiol Scand; 1988 Jul; 32(5):374-8. PubMed ID: 3046220.
    Abstract:
    Fluctuating PEEP (F-PEEP) is a newly developed PEEP in which end-expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F-PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C-PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F-PEEP produced a significantly greater improvement of PaO2 and intrapulmonary shunt (QS/QT) than C-PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F-PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury.
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