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  • Title: [Differences in the excitatory action of acetylcholine and mecholine on mechanosensitive high-threshold C-axonal units of the skin in the cat].
    Author: Selektor LIa, Ermishkin VV, Revenko SV, Khaiutin VM.
    Journal: Biull Eksp Biol Med; 1988 Aug; 106(8):183-7. PubMed ID: 3046674.
    Abstract:
    Intraarterial acetylcholine (Ach) and acetyl-beta-methylcholine (metacholine, Mch) excite feline high-threshold C-fiber mechanosensitive cutaneous sensory units (SU) in a different way. Ach in noxious (algogenic for humans) concentrations of 10 micrograms/ml and more induces a high-frequency discharge, with mean frequency of impulses at its peak being 4-12 Hz. This discharge seems to result from activation of N-cholinoreceptors because non-noxious and nonalgogenic M-agonist Mch as well as Ach in subnoxious concentrations induce in SU only a low-frequency discharge with a mean frequency of impulses 0.5-3.5 Hz. The data are discussed in connection with nociception and tissue chemoreception.
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