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  • Title: [Influencing of the kininogen-Kinin-System by means of a kallikrein-inhibitor during extracorporeal circulation in open heart surgery (author's transl)].
    Author: Deklerk J, Benzer H, Haider W, Pauser G, Stellwag F.
    Journal: Anaesthesist; 1977 Dec; 26(12):639-43. PubMed ID: 304691.
    Abstract:
    During extracorporeal circulation for open heart surgery an activation of the kininogen-kininsystem occurs with a decrease in plasma-kininogen-levels significantly exceeding the effect of haemodilution, and thus being due to an increased liberation of kinin. This effect could be suppressed by kallikrein inhibition by means of a protease-inhibitor.
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