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  • Title: A carbapenem-based fluorescence assay for the screening of metallo-β-lactamase inhibitors.
    Author: Qian X, Zhang S, Xue S, Mao W, Xu M, Xu W, Xie H.
    Journal: Bioorg Med Chem Lett; 2019 Jan 15; 29(2):322-325. PubMed ID: 30470495.
    Abstract:
    Reported herein is a fluorescence assay for the rapid screening of metallo-β-lactamase (MBL) inhibitors. This assay employs a fluorogenic carbapenem CPC-1 as substrate and is compatible with all MBLs, including B1, B2 and B3 subclass MBLs. The efficiency of this assay was demonstrated by the rapid inhibition screening of a number of molecules against B2 MBL CphA and 2,3-dimercaprol was identified as a potent CphA inhibitor.
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