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  • Title: The origin of the Sternberg cell.
    Author: Schwarz O, Dormont D, Lesser J, Andrieu JM.
    Journal: Nouv Rev Fr Hematol (1978); 1988; 30(3):183-9. PubMed ID: 3047670.
    Abstract:
    The Sternberg cell, the malignant cell of Hodgkin's disease, remains of uncertain nature 80 years after it was first described. Numerous hypotheses have been advanced as to its origin: that it derives from the macrophages, B lymphocyte, T lymphocyte, interdigitating reticulum cell or even from an as yet unidentified cell-line. We here review these various hypotheses, as well as the different techniques used for its study. The morphologic, ultrastructural, histochemical and immunologic studies are discussed in detail.
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