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  • Title: 60Co gamma-rays induce predominantly C/G to G/C transversions in double-stranded M13 DNA.
    Author: Hoebee B, Brouwer J, van de Putte P, Loman H, Retèl J.
    Journal: Nucleic Acids Res; 1988 Aug 25; 16(16):8147-56. PubMed ID: 3047678.
    Abstract:
    Upon irradiation with gamma rays of an oxygenated aqueous solution of double-stranded M13 DNA, a very specific mutation spectrum was found with respect to both the type and the positions in the DNA sequence. Of the 23 mutations, which were sequenced, 16 represent a C/G to G/C transversion. A C/G to T/A transition was found once and a G/C to T/A transversion twice. The remaining 4 mutations are frameshifts, 2 are identical and formed by the insertion of a G/C basepair; the other 2 mutations are due to a duplication of 10 basepairs situated at different positions but with a remarkable homology in base sequence. Fourteen mutations, including the 2 duplications are found in the neighbourhood of a TGCT/ACGA sequence.
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