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  • Title: [Malignant histiocytosis (author's transl)].
    Author: Huhn D, Meister P, Thiel E, Bartl R, Theml H.
    Journal: Dtsch Med Wochenschr; 1978 Jan 13; 103(2):55-61. PubMed ID: 304801.
    Abstract:
    According to observations in six patients and published reports, malignant histiocytosis is characterized by premature multifocal proliferation of atypical histiocytes, especially in lymph-nodes, spleen, liver, bone marrow, and lung. The diagnosis can be confirmed by electron-microscopy, and enzyme as well as immunocytochemical tests. Fever, anaemia, leukopenia (with absolute reduction in T-lymphocytes), and jaundice are frequent. Immunoglobulins are normal or polyclonally increased. Malignant histiocytosis is more like monocyte leukaemia and histiocytosis X than neoplasms of the lymphatic system.
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