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  • Title: Reduction in peripheral blood K cells and activated T cells in primary biliary cirrhosis.
    Author: Sandilands GP, Macsween RN, Gray KG, Holden RJ, Mills P, Reid FM, Thomas MA, Watkinson G.
    Journal: Gut; 1977 Dec; 18(12):1017-20. PubMed ID: 304826.
    Abstract:
    Lymphocyte subpopulations were measured in the peripheral blood of 13 patients with primary biliary cirrhosis (PBC), 13 with chronic active hepatitis (CAH), and 16 age- and sex-matched normal subjects. A significant, relative and absolute, reduction in activated T cells and K cells, compared with that in normal subjects, was found in PBC but not in CAH. The reduction in K cells observed in PBC was found to be accompanied by a parallel decrease in lymphocyte-mediated antibody-dependent cytotoxicity.
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