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  • Title: Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications.
    Author: Wang Q, Wang S, Hu X, Li F, Ling D.
    Journal: Biomater Sci; 2019 Jan 29; 7(2):480-489. PubMed ID: 30488906.
    Abstract:
    Inorganic nanomaterials have been studied extensively in recent years because of their unique physical and chemical characteristics. Moreover, ultra-small nanoclusters (USNCs), which are less than 3 nm in size, exhibit extraordinary properties different from those of larger-sized nanoparticles. For example, ultra-small iron oxide nanoclusters (NCs) show paramagnetic properties; ultra-small noble metal NCs exhibit bright fluorescence; most USNCs gain in vivo renal clearance capability to guarantee safety. Therefore, USNCs could be promising safe materials for biomedical applications. In this mini-review, we summarize recent advances in the controlled synthesis, assembly, and biomedical applications of USNCs. We also discussed future challenges and perspectives in the development of USNC-based nanomedicine.
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