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  • Title: Globo-A--a new receptor specificity for attaching Escherichia coli.
    Author: Senior D, Baker N, Cedergren B, Falk P, Larson G, Lindstedt R, Edén CS.
    Journal: FEBS Lett; 1988 Sep 12; 237(1-2):123-7. PubMed ID: 3049148.
    Abstract:
    Uropathogenic Escherichia coli strains designated as ONAP, based on their O negative A positive agglutination of human P1 erythrocytes, were shown to prefer the globo-A glycolipid as a receptor structure. The dependence on both the A terminal and the globoseries chain was confirmed by agglutination of human AP1, but not Ap or OP1 erythrocytes and by binding to the globo-A glycolipid on TLC plates. Neither Gal alpha 1----4Gal beta nor the A trisaccharide GalNAc alpha 1----3(Fuc alpha 1----2)Gal beta alone functioned as receptors. The bacteria thus appeared to recognize an epitope resulting from the combination of the terminal and internal structures.
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