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  • Title: Treatment of epidemic Kaposi's sarcoma with a combination of interferon-alpha 2b and etoposide.
    Author: Krigel RL, Slywotzky CM, Lonberg M, Green MD, Andes WA, Kempf R, Gupta S, Grace W, Spiegel RJ, Muggia FM.
    Journal: J Biol Response Mod; 1988 Aug; 7(4):359-64. PubMed ID: 3049944.
    Abstract:
    A prospective clinical trial of concomitant interferon-alpha 2b and etoposide was conducted in 24 previously untreated patients with epidemic Kaposi's sarcoma. Eight of 21 evaluable patients (38%) achieved either a complete response (1 patient) or a partial response (7 patients). None of the responders had a prior history of opportunistic infection. Hematologic toxicity was severe, and 8 patients developed an opportunistic infection. The combination of interferon-alpha 2b and etoposide has modest activity, but no additive or synergistic activity was evident in the dose and schedule utilized in this study. The exact role for interferon-alpha in epidemic Kaposi's sarcoma, both as a single agent and in combinations, remains to be determined.
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