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  • Title: Polysaccharides from Tetrastigma hemsleyanum Diels et Gilg: Extraction optimization, structural characterizations, antioxidant and antihyperlipidemic activities in hyperlipidemic mice.
    Author: Ru Y, Chen X, Wang J, Guo L, Lin Z, Peng X, Qiu B.
    Journal: Int J Biol Macromol; 2019 Mar 15; 125():1033-1041. PubMed ID: 30500505.
    Abstract:
    In this study, a novel polysaccharide TDGP-3 from Tetrastigma hemsleyanum Diels et Gilg was extracted by enzymolysis-ultrasonic assisted extraction (EUAE) method and its antioxidant and hypolipidemic activities were evaluated. With a molecular weight of 3.31 × 105 Da, TDGP-3 was composed of 1,4-Glcp, 1,4-Glap and 1,3,6-Manp linkage in the main chain. TDGP-3 showed potential effects on relieving hyperlipidemia and preventing oxidative stress, reflecting by regulating blood lipid levels (TC, TG, HDL-C and LDL-C), decreasing the contents of MDA in liver, restoring the activities of hepatic antioxidant enzymes (SOD, GSH-Px and CAT). The results clearly indicated that the TDGP-3 possesses a potent hypolipidemic activity and might be used for hyperlipidaemia treatment.
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