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  • Title: Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ.
    Author: Impicciatore M.
    Journal: Br J Pharmacol; 1978 Oct; 64(2):219-22. PubMed ID: 30504.
    Abstract:
    1 Histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through H1- and H2-receptor stimulation respectively. 2 The contracturant action, mimicked by 2-(2-aminoethyl) thiazole (a specific H1-receptor agonist), is blocked by mepyramine and the relaxation, mimicked by dimaprit (a specific H2-receptor agonist), is inhibited by cimetidine.
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