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  • Title: [The biological action spectrum of the secretory products of the human B-cell lymphoblastoid line RPMI-641Ot].
    Author: Seregina TM, Mekshenkov MI.
    Journal: Ontogenez; 1988; 19(3):240-6. PubMed ID: 3050669.
    Abstract:
    Secretory products of the lymphoblastoid line of human B-cells RPMI-6410t have a wide spectrum of biological activity. These products exert a growth-stimulating effect on B-cells of the 6410t strain obtained from the peripheral blood of a patient with acute myeloblastic leukemia and cytotoxic and cytostatic effects, respectively, on B-cells of the Raji and P3HR-I.G5 lines obtained from patients with Burkitt's lymphoma. They also exert a cytotoxic effect on murine L-cells. Biological activity is relieved at 70 degrees and at low and high pH.
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