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  • Title: Inhibition of B cell cytotoxicity by aggregated IgG and immune complexes.
    Author: d'Apice AJ, Tait BD, Lambert G.
    Journal: Tissue Antigens; 1977 Nov; 10(5):273-8. PubMed ID: 305139.
    Abstract:
    The presence of immune complexes or aggregated IgG in the microlymphocytotoxicity assay may cause inhibition of cytoxity. When HLA-A and-B antigens are the subject of the test the effect is minimal; however, when B cell alloantigens are being examined the effect is marked. The pattern of inhibition in the later case and the fact that B lymphocytes preincubated with immune complexes are resistant to cytotoxic lysis by anti-B cell sera suggests that immune complexes and aggregated IgG inhibit cytotoxicity by prevention of antibody binding rather than by complement consumption.
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