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  • Title: Oxidative Addition to Palladium(0) Made Easy through Photoexcited-State Metal Catalysis: Experiment and Computation.
    Author: Kancherla R, Muralirajan K, Maity B, Zhu C, Krach PE, Cavallo L, Rueping M.
    Journal: Angew Chem Int Ed Engl; 2019 Mar 11; 58(11):3412-3416. PubMed ID: 30520235.
    Abstract:
    Visible-light induced, palladium catalyzed alkylations of α,β-unsaturated acids with unactivated alkyl bromides are described. A variety of primary, secondary, and tertiary alkyl bromides are activated by the photoexcited palladium metal catalyst to provide a series of olefins at room temperature under mild reaction conditions. Mechanistic investigations and density functional theory (DFT) studies suggest that a photoinduced inner-sphere mechanism is operative in which a barrierless, single-electron transfer oxidative addition of the alkyl halide to Pd0 is key for the efficient transformation.
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