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  • Title: Reproductive Homeostasis and Senescence in Drosophila melanogaster.
    Author: Curtsinger JW.
    Journal: J Gerontol A Biol Sci Med Sci; 2019 Sep 15; 74(10):1533-1538. PubMed ID: 30521013.
    Abstract:
    The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. The collapse of homeostatic capacity is abrupt. Enhanced homeostasis is associated with increased lifetime fecundity and improved prospects for survival. The fractal concept of lacunarity can be used to parameterize the "roughness" of individual fecundity trajectories and is inversely related to homeostatic capacity.
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