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  • Title: [Clinicopathologic and molecular features of myoepithelial tumors of salivary glands].
    Author: Ni H, Wu N, Wang XT, Xia QY, Wang X, Shi SS, Li R, Zhou XJ, Rao Q.
    Journal: Zhonghua Bing Li Xue Za Zhi; 2018 Dec 08; 47(12):936-940. PubMed ID: 30522175.
    Abstract:
    Objective: To investigate the clinicopathological, and molecular characteristics of myoepithelial tumors (MTs) of salivary glands. Methods: A total of 37 MTs cases including 13 malignant epithelial tumors (MMTs) and 24 benign epithelial tumors (BMTs) of salivary glands were identified from the archives of the Department of Pathology, General Hospital of Eastern Theater Command, dating from 2006 to 2016. Clinical features, histological patterns, immunohistochemical characteristics and status of EWSR1 gene rearrangement by fluorescence in situ hybridization (FISH) analysis were reviewed in all cases. Results: Clinically, 37 MTs cases mainly occurred in the parotid glands, when most of the patients presented with painless masses. Of the 13 MMTs cases, male to female ratio was 7∶6, and the median age was 62 years old. Of the 24 BMTs cases, male to female ratio was 5∶7, and the median age was 54 years old. Immunohistochemically, 37 MTs cases were positive for CKpan, and at least one myoepithelial marker. Twenty six of 37 MTs cases were analyzable for the EWSR1 gene break by FISH. Based on the previous evaluation criterion, the EWSR1 translocation was detected in 4 cases of 11 MMTs, and 4 cases of 15 BMTs. According to the main histological composition of tumor cells, 4 EWSR1-positive MMTs covered 2 clear-cell cases and 2 epithelioid-cell cases, when 4 EWSR1-positive BMTs covered 2 clear-cell cases, 1 plasmacytoid-cell case, and 1 spindle-cell case. Conclusions: Males and females are affected equally. MTs express immunoreactivity for CKpan, and at least one myoepithelial marker. The EWSR1 rearrangement is present in a subset of MTs, with variable morphological characteristics, and has no statistical significance on clinical behavior. 目的: 探讨涎腺肌上皮肿瘤(myoepithelial tumor, MT)的临床病理及分子病理学特征。 方法: 回顾性分析解放军东部战区总医院病理科2006—2016年手术切除的涎腺肿瘤标本,筛选出37例MT,其中恶性13例,良性24例。所有病例均进行了临床资料采集、组织学形态观察和免疫组织化学染色,并利用荧光原位杂交(FISH)法检测EWSR1基因重排情况,归纳本研究中FISH阳性MT的形态特点以及EWSR1基因重排检测在判断该肿瘤临床生物学行为中的作用。 结果: 37例MT均发生于腮腺,患者多以无痛性肿块就诊。13例恶性MT中,男性7例,女性6例,中位年龄62岁;24例良性MT中,男女比5∶7,中位年龄54岁。37例(100%)MT均广谱细胞角蛋白(CKpan)阳性,并表达p63、S-100蛋白、Calponin、CK14中至少1种肌上皮标志物。26例检测到EWSR1信号,其中8例(4例恶性MT、4例良性MT)EWSR1分离探针检测阳性。根据MT肿瘤细胞主要形态划分,4例EWSR1重排阳性的恶性MT中,2例呈透明细胞样,2例呈上皮样组织学形态;4例EWSR1重排阳性的良性MT中,有2例呈透明细胞样、1例呈浆细胞样、1例呈梭形细胞形态。 结论: MT多发于腮腺,男女发生比例相近。MT均表达CKpan,并至少表达1种肌上皮标志物。EWSR1基因重排存在于一部分MT中,伴有该重排的MT形态学特征多样,EWSR1基因重排检测对于判断该肿瘤临床生物学行为价值不大。.
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