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  • Title: A dual-responsive fluorescent probe for detection of fluoride ion and hydrazine based on test strips.
    Author: Wang X, Zhou Y, Xu C, Song H, Pang X, Liu X.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2019 Mar 15; 211():125-131. PubMed ID: 30530065.
    Abstract:
    Hydrazine (N2H4) and fluoride ion (F-) are regarded as environmental pollutants and potential carcinogens. A dual-functional fluorescent probe (probe 1) was developed for both F- and N2H4 with high selectivity and sensitivity. 1 was based on nucleophilic aromatic substitution reaction for N2H4 detection and selective cleavage of 4-nitrobenzenesulphonyl group for the determination of F-. The limits of detection of probe for F- and N2H4 were 77.82 nM and 29.34 nM, respectively, which are far below the threshold limit value (TLV) of United States Environmental Protection Agency (EPA). The home-made test strips of 1 provided the positive tool for F- and gaseous N2H4 in different system. And the confocal fluorescence images indicated that 1 can quantitatively detect N2H4 in living PC12 cells. Promisingly, 1 has great prospects for N2H4 imaging and determining in living system.
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