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  • Title: Effect of interleukin-1 antagonists on the quality of life in familial Mediterranean fever patients.
    Author: Varan O, Kucuk H, Babaoglu H, Atas N, Salman RB, Satis H, Ozturk MA, Haznedaroglu S, Goker B, Tufan A.
    Journal: Clin Rheumatol; 2019 Apr; 38(4):1125-1130. PubMed ID: 30535829.
    Abstract:
    BACKGROUND: Familial Mediterranean fever (FMF) patients suffer from chronic complications of disease such as AA amyloidosis, chronic arthritis, and spondylitis. Reduced quality of life (QoL) is a feature of chronic diseases but it is also impaired in patients with FMF. Despite the regular use of colchicine at a maximal dose, about 10% of patients do not respond well or resistant to colchicine (crFMF). IL-1 inhibitors have been shown to be effective in controlling attacks in crFMF patients. Herein, we aimed to investigate QoL changes of crFMF patients with IL-1 inhibitors. METHODS: All patients were prospectively monitored for the frequency, duration, severity of attacks, patient global assessments (Visual Analog Scale; VAS), and laboratory features. Either anakinra or canakinumab was used as IL-1 antagonist treatments. Demographic information, MEFV gene mutations, attack characteristics, and previous treatments were registered. Short form-36 (SF-36) quality of life scale was implemented by the interviewer for evaluating the QoL before and 3 months after the treatment. RESULTS: A total of 44 patients were included in this study. Striking improvements were detected in frequency, duration, and VAS severity of attacks (p < 0.001). In the comparison of pre- and post-treatment, SF-36 sub-components significant improvements were observed on physical function, role limitation due to physical difficulty, role limitation due to emotional problem, energy, emotional well-being, social function, pain, general health, and health change. CONCLUSIONS: In conclusion, IL-1 antagonists prevent attacks and improve QoL of crFMF.
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