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  • Title: Steady-state evaluation of two controlled-release theophylline preparations in children.
    Author: Tinkelman DG, Lutz CN, Crummie A, Harrison LI, McCarville SE, Bastyr MH.
    Journal: J Asthma; 1988; 25(1):27-31. PubMed ID: 3053601.
    Abstract:
    The absorption profiles of Theolair-SR and Theo-Dur were studied in 23 asthmatic children (mean age 11 years). A 250-mg dose of each product was administered twice a day until steady state was attained (mean, 8 days). Both products maintained adequate theophylline levels over 12 hours, although Theolair-SR gave significantly higher serum levels and a 19% greater extent of theophylline absorption. The mean Cmax-Cmin was also significantly greater for Theolair-SR. Both products should be considered comparable for practical use.
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