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  • Title: Rapid Synthesis of γ-Arylated Carbonyls Enabled by the Merge of Copper- and Photocatalytic Radical Relay Alkylarylation of Alkenes.
    Author: Lv XL, Wang C, Wang QL, Shu W.
    Journal: Org Lett; 2019 Jan 04; 21(1):56-59. PubMed ID: 30543433.
    Abstract:
    The development of mild and practical methods for the γ-arylation of carbonyl compounds is an ongoing challenge in organic synthesis. The first formal γ-arylation of carbonyl compounds via radical relay cross-coupling of α-bromocarbonyl precursors with boronic acids in the presence of alkenes is reported. This directing-group-free protocol allows for the rapid and straightforward access to a wide range of γ-arylated esters, ketones, and amides under ambient conditions with excellent functional group tolerance.
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