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  • Title: Evaluation of plan quality and treatment efficiency for single-isocenter/two-lesion lung stereotactic body radiation therapy.
    Author: Sanford L, Molloy J, Kumar S, Randall M, McGarry R, Pokhrel D.
    Journal: J Appl Clin Med Phys; 2019 Jan; 20(1):118-127. PubMed ID: 30548205.
    Abstract:
    PURPOSE/OBJECTIVES: To evaluate the plan quality and treatment delivery efficiency of single-isocenter/two-lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT). MATERIALS/METHODS: Eight consecutive patients with two peripherally located early stage nonsmall-cell-lung cancer (NSCLC) lung lesions underwent single-isocenter highly conformal noncoplanar VMAT SBRT treatment in our institution. A single-isocenter was placed between the two lesions. Doses were 54 or 50 Gy in 3 and 5 fractions respectively. Patients were treated every other day. Plans were calculated in Eclipse with AcurosXB algorithm and normalized to at least 95% of the planning target volume (PTV) receiving 100% of the prescribed dose. For comparison, two-isocenter plans (isocenter placed centrally in each target) were retrospectively created. Conformity indices (CIs), heterogeneity index (HI), gradient index (GI), gradient distance (GD), and D2cm were calculated. The normal lung V5, V10, V20, mean lung dose (MLD) and other organs at risk (OARs) doses were evaluated. Total number of monitor units (MUs), beam-on time, and patient-specific quality assurance (QA) results were recorded. RESULTS: The mean isocenter to tumor distance was 6.7 ± 2.3 cm. The mean combined PTV was 44.0 ± 23.4 cc. There was no clinically significant difference in CI, HI, GD, GI, D2cm , and V20 including most of the OARs between single-isocenter and two-isocenter lung SBRT plans, evaluated per RTOG guidelines. However, for single-isocenter plans as the distance between the lesions increased, the V5, V10, and MLD increased, marginally. The total number of MUs and beam-on time was reduced by a factor of 1.5 for a single-isocenter plan compared to a two-isocenter plan. The single-isocenter/two-lesions VMAT lung SBRT QA plans demonstrated an accurate dose delivery of 98.1 ± 3.2% for clinical gamma passing rate of 3%/3 mm. CONCLUSION: The SBRT treatment of two peripherally located lung lesions with a centrally placed single-isocenter was dosimetrically equivalent to two-isocenter plans. Faster treatment delivery for single-isocenter treatment can improve patient compliance and reduce the amount of intrafraction motion errors for well-suited patients.
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