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  • Title: Significance of intraparotid node metastasis in predicting local control in primary parotid cancer.
    Author: Feng Y, Liu F, Cheng G, Fang Q, Niu X, He W.
    Journal: Laryngoscope; 2019 Oct; 129(10):2309-2312. PubMed ID: 30549298.
    Abstract:
    OBJECTIVE: To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing the significance of IGLN metastasis in local control (LC) of parotid gland cancer (PGC). METHODS: A total of 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, IGLN metastasis, and follow-up findings was extracted and analyzed. RESULTS: IGLN metastasis was noted in 111 (32.9%) patients. Tumor stage, pathologic nodal stage, perineural invasion, resection status, and lymphovascular invasion were significantly related to IGLN metastasis. Local recurrence was noted in 67 (19.9%) patients. IGLN metastasis was an independent predictor of LC. The 10-year LC rate was 94% for patients without IGLN metastasis, 56% for patients with metastasis in no more than two IGLNs, and 22% for patients with metastasis in more than two IGLNs. This difference was significant (P < 0.001). CONCLUSION: The IGLN metastasis rate is relatively high in PGC patients and is significantly associated with disease grade and T stage. IGLN metastasis is associated with poorer local LC, and patients with more than two metastatic nodes have the worst prognosis. LEVEL OF EVIDENCE: 4 Laryngoscope, 129:2309-2312, 2019.
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