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  • Title: Insect heart rhythmicity is modulated by evolutionarily conserved neuropeptides and neurotransmitters.
    Author: Hillyer JF.
    Journal: Curr Opin Insect Sci; 2018 Oct; 29():41-48. PubMed ID: 30551824.
    Abstract:
    Insects utilize an open circulatory system to transport nutrients, waste, hormones and immune factors throughout the hemocoel. The primary organ that drives hemolymph circulation is the dorsal vessel, which is a muscular tube that traverses the length of the body and is divided into an aorta in the head and thorax, and a heart in the abdomen. The dorsal vessel is myogenic, but its rhythmicity is modulated by neuropeptides and neurotransmitters. This review summarizes how neuropeptides such as crustacean cardioactive peptide (CCAP), FMRFamide-like peptides, proctolin, allatotropin and allatostatin modulate the heart contraction rate and the directionality of heart contractions. Likewise, it discusses how neurotransmitters such as serotonin, octopamine, glutamate and nitric oxide influence the heart rate, and how transcriptomic and proteomic approaches are advancing our understanding of insect circulatory physiology. Finally, this review argues that the immune system may modulate heart rhythmicity, and discusses how the myotropic activity of cardioactive factors extends to the accessory pulsatile organs, such as the auxiliary hearts of the antennae.
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