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  • Title: Microwave assisted κ-carrageenan capped silver nanocomposites for eradication of bacterial biofilms.
    Author: Goel A, Meher MK, Gupta P, Gulati K, Pruthi V, Poluri KM.
    Journal: Carbohydr Polym; 2019 Feb 15; 206():854-862. PubMed ID: 30553393.
    Abstract:
    Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. CRG-Ag nanoparticles were highly effective against both S. aureus and P. aeruginosa mediated biofilms and acted as a broad spectrum antibacterial agent even after six months. CRG-Ag nanoparticles encapsulated in KCl cross-linked hydrogel also exhibited excellent thermal stability, and antimicrobial potency. All these results depict that CRG-Ag nanocomposites appear as a promising approach to eradicate bacterial biofilms in food packaging and biomedical applications.
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